Target Attainment and Population Pharmacokinetics of Nirmatrelvir/Ritonavir in Critically Ill Adult Patients
Introduction Nirmatrelvir/ritonavir (NIR/RIT, Paxlovid) is a novel oral medication designed to inhibit the 3‐chymotrypsin‐like cysteine protease (Mpro) of severe acute respiratory syndrome coronavirus-2 (SARS‐CoV‐2).1 NIR is metabolized primarily …